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At the beginning of the treatment, 1 ampoule with 1 mlvitamin B 12 Lichtenstein (corresponding to 1000 micrograms of cyanocobalamin) is added twice a week in the first weeks after diagnosis.12 Lichtenstein is usually administered intramuscularly (injected into a muscle)

Selectivity for Cu I is mediated by a negative design element, a conserved Ser in the 5 helix, required to exclude divalent metal ions, 317,343,344 as well as the somewhat shorter length of the MBL relative to divalent metal sensors (Figure 11F)

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