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3.4 SPAE enhances antioxidant defense and reduces oxidative stress The effect of SPAE and DEX on lipid peroxidation marker (MDA& NO) levels and antioxidant enzyme (CAT & SOD) activity in rat liver tissues

In some embodiments, the positively charged protein in the complex has reduced solubility and therefore is released slowly from the formulation

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In PK15 cells, using the increased expression of DNMT1 , OTA can induce nephrotoxicity (15), with the underlying mechanism involving apoptosis, cell cycle arrest, DNA damage, and inhibited protein synthesis (16)

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This reduces the risk of over-supplementation and adverse effects, which are common when supplement use is unmanaged