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2017;16(5):7432-7438.doi:10.3892/mmr.2017.7546 Sanders KM, Stuart AL, Williamson EJ,et al

Mechanistically, NETderived histones bind to endothelial cell TLR2/TLR4 and trigger NFB and MAPKmediated upregulation of adhesion molecules (ICAM1, VCAM1, Eselectin), thereby promoting neutrophil and platelet tethering [81]

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Combination therapy of Ad-mda7 and Herceptin inhibits tumor growth in nude mice and increases apoptosis in Her2/neu overexpressing breast cancer cells