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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines

Jiang X, Mak PY, Mu H, Mak D, Zhang Q, Konopleva M, Andreeff M , Carter BZ

This occurs through noncatalytic stimulation by cytosolic cis-aconitate decarboxylase 1, which is upregulated in response to mycobacterial infection (Yang et al., 2025)

By working with neurotransmitters, mood regulation circuits, and possibly the hypothalamic-pituitary axis, DSIP may help reduce excessive stress hormones (like cortisol) and reduce the nervous systems on-edge state

These findings confirmed that the fullerenols particles used in our study possessed typical nanoparticle characteristics and met the experimental requirements