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The addition of the C-20 fatty acid moiety to Lys20 is hypothesized to increase the binding dose-response ratio due to an increased albumin affinity

Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992)

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Having two distinct methods (i.e., the GNPT-coatomer interaction and the LYSET-GOLPH3 interaction) for recycling GNPT at the Golgi and a third to retrieve any escaped enzyme ensures the robustness of the M6P pathway, minimizing the risk of its compromise

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