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doi: 10.1007/s00213-014-3650-y 111 MahmoodD.KhanamR.PillaiK

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Open question No published Phase 2 or Phase 3 human RCT exists

early studies showed that ITCs block new blood vessel formation and epithelialmesenchymal transition (EMT) in tumors (122)

In particular, it has been demonstrated that Zn stimulates oligomerization of higher molecular weight forms of adiponectin through modulation of disulfide bond formation [85]

In support of this concept, knockdown of CaSR expression blocks the ability of high extracellular Ca 2+ concentrations ([Ca 2+ ] e ) to promote cell differentiation and matrix mineralization in cultured chondrocytes (46)