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Further support comes from cross-sectional studies comparing PD and matched control subjects 13 , while others have investigated the role of UA in disease progression and severity, with findings suggesting an influence of low UA in each of these clinical factors 14,15

Initial research suggested that the memory-enhancing effects often attributed to AngII were, in fact, mediated by its conversion to AngIV, acting at the AT4 receptor subtype

Nutrients 15:317

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Each works through a different mechanism, and the evidence levels are very different

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