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Lopez-Fabuel, I

Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways

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Future studies evaluating glutathione with a larger sample size with statistical power to differentiate the association proposal by manic or depressive episodes, as well as the use of NAC as a suicide risk reducer, seem justified

For example, erastin can inhibit cystine uptake and synthesis of GSH by blocking system Xc - , thereby promoting ferroptosis progression[10]

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