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PGC-1 is a master regulator of mitochondrial lifecycle and ROS stress response
(DMEM/F12, Gibco, Gaithersburg, USA) supplemented with 10% heat-inactivated fetal bovine serum (FBS, Gibco, Gaithersburg, USA) and 1% penicillin/streptomycin (Invitrogen, Life Technologies, USA) in a humidified incubator with 5% CO 2 at 37 C
Heres where it matters most
It is involved in bone formation, macronutrient metabolism, and defense systems against free radicals [116] and plays a fundamental role in brain function and development [117]
Sasha Rose, ND, LAc, MSOM Forbes Health Advisory Board Naturopathic Doctor Updated June 4, 2026 Did you know a single high dose Vitamin C IV therapy can give your body up to 50 times more vitamin C than a healthy diet
