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The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system ( Treg cells mainly fall into four categories and use direct or indirect interaction to carry out immunosuppressive actions: 1) Cytokine-mediated suppression: TGF-, IL-10, and IL-35 induce Treg development, prevent antigen-presenting cell (APC) maturation, and mediate bystander suppression ( 3 Metabolic programs governing the Th17/Treg balance Metabolic reprogramming critically controls Th17 and Treg cell fate

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Experimental data indicate that increased PER1 expression may enhance the susceptibility of tumor cells to ionizing radiation, potentially affecting thresholds for radiation-induced cell death in in vitro and in vivo systems

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In the kidney, the concentration was approximately 0.1-fold within 15 min (0.25 h)