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Both male and female mice treated with intranasal GHK-Cu had significantly lower concentrations of NFL-1 in the frontal cortex compared to intranasal saline treated cohorts (Figure 4C) indicating GHK-Cu was able to attenuate axonal damage associated with brain aging in C57BL/6 mice

Hosseini, S., Marco, P

Kopetz S , Jiang Z, Overman MJ, Rosenberg R, Salazar R, Tabernero J, Stork L, Li Y, Simon I, Chang GJ, Maru DM

Activation of caspase-8 facilitates the execution of apoptosis, simultaneously inhibiting necroptosis by preventing RIPK1 recruitment, a key regulator of necroptosis

The brain accounts for 2% of total body weight but consumes about 20% of the body oxygen