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doi: 10.1016/j.lfs.2021.120046 30 OwenKLBrockwellNKParkerBS

It is typically used in tiny amounts, around 0.1% or less.

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Thiamine hydrochloride (vitamin B1) in the formulation is known to cause life threatening anaphylaxis especially on multiple administrations if patient is allergic to it

"Double-blind" means neither patients nor doctors know who is in which group eliminating both placebo effects and evaluator bias

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