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Peptides were separated using an Acclaim Pepmap 100 trap column (75 micron ID 2 cm from Themo Scientific) and eluted onto an Acclaim PepMap RSKC analytical column (75 micron ID x 2 cm, Thermo Scientific) with a gradient of solvent A (water and 0.1% formic acid) and solvent B (acetonitrile and 0.1% formic acid)

The pro-oxidant effect of resveratrol has also associated with its toxic influence upon cellular viability

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Given the burden of cognitive dysfunction, a better understanding of biological underpinnings is crucial, and MRS allows a unique insight into biochemical changes linked to cognitive performance