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An imbalance (excess/reduction) of K+, Na+-channels (encoded by the SCN5A gene), Ca2+, as well as ion channel disturbances, together with various DNA and mitochondrial alterations represent the most important triggers in initiation and abnormal nervous conduction, thus leading to arrhythmogenesis
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Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
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