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Prescription Drugs That May Lead to Heart Damage The American Heart Association (AHA) lists the following prescription drugs as causing or intensifying the risk of heart failure: AnalgesicsNSAIDs Traditional non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, indomethacin, diclofenac, and ketorolac inhibit the COX-1 isoenzyme, creating an adverse effect on platelet aggregation (how well platelets clump together to form blood clots), maintenance of the bodys gastric mucosal barrier (allowing the stomach to safely contain gastric acid), and renal function

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