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This paper investigates the malignant progression of BE to EAC by whole-exome sequencing and shows that the emergence of EAC follows a more rapid pathway that involves genome duplication

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The end result wrinkles and sagging skin

doi: 10.1152/ajpgi.00048.2010 60 RitchieJWABairdFEChristieGRStewartALowSYHundalHSet al