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"This is the first study based on residue analysis that has yielded positive results for nicotine in well-documented vessels recovered during archaeological excavations anywhere in Mesoamerica," study co-author Oswaldo Chinchilla Mazariegos of Yale University told Newsweek

Medications for nicotine replacement include bupropion, nortriptyline, clonidine, and varenicline

Li, Z., et al

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The pipes used for opium-smoking in various parts of the East have small bowls