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In vivo studies reported that treatment with L-Carnitine increases the expression of BCl-2 and reduces Bax expression in situations where spermatogenesis is compromised, leading to apoptosis in the testes and decreased testosterone secretion [69]

With respect to the cost criterion, the applicant provided two analyses to demonstrate that it meets the cost criterion, with the primary analysis excluding claims from hospitals with 11 or fewer cases, and the second analysis based on all identified claims within the same MS-DRGs identified in the primary analysis, as described in further detail in the following table

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Refluxed blood promotes the Fenton reaction, terminating in the production of hydroxyl radical, the most potently destructive ROS

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Chronic selenium supplementation risks toxicity, with case reports of selenosis highlighting the narrow therapeutic margin (287)