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Such consequences may include obesity, enteritis, diabetes, and metabolic syndrome

In one double-blind, randomized, placebo-controlled trial in patients with liver disease and thrombocytopenia about to undergo an invasive procedure, pretreatment with 75 mg eltrombopag daily for 2 weeks significantly reduced the need for platelet transfusions (Afdhal 2012)

You can also think of GSH as the active, working form of the molecule

Therefore, intracellular GSH depletion or GPX4 inactivation induced by various factors will decrease the clearance rate of toxic lipid peroxides and result in ferroptosis

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