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There is no evidence to suggest that consuming alcohol before getting a COVID vaccine impacts the vaccines effectiveness, though some experts recommend avoiding alcohol 24 hours before vaccination

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10.1126/science.1077209 Science 20 BrakedalB.FlnesI.ReiterS

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This distinction is crucial: most fundamental studies on the actin mechanism focus on the entire T4, and extrapolation to the TB-500 fragment alone remains incomplete in the published literature