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It has been reported that AKI affected more than 13.3 million patients with about 1.7 million deaths around the world each year, and the mortality was AKI stage-dependent (Brown et al., 2016)

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221 , e20230774 (2024)

Dombrowski Y, Peric M, Koglin S, Ruzicka T, Schauber J: Control of cutaneous antimicrobial peptides by vitamin D3

This changes the in vivo distribution of the nanoparticle carriers, induces inflammatory responses, disrupts the stability of the formulation, and even triggers hypersensitivity reactions [217]