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These compounds can exacerbate immune responses and induce oxidative stress, thereby contributing to additional tissue damage (190)

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This is consistent with our results indicating that the GSH level decreased and ROS level increased in the testis of 16-month-old WT mice

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They play an essential role in the amplification of the inflammatory cascade, through the secretion of chemokines and cytokines [5,6,7]

Further to the above, physiological processes that degrade ROS are known to be impaired in neurodegenerative diseases and as a consequence of aging