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Treatment with 500 mg/kg BSO caused no detectable changes in the size of xenograft tumors, and treatment with 6 mg/kg DPI alone caused a decrease of 18.5% in tumor size

Therefore, raising cellular NAD + through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD + precursors becoming a popular supplementation approach

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[PMC free article] [PubMed] [Google Scholar] 170.Buonocore D., Grosini M., Giardina S., Michelotti A., Carrabetta M., Seneci A., Verri M., Dossena M., Marzatico F