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Furthermore, enhanced inactivation of the vasodilator NO by O2- may explain the observed relationship between ROS, in particular superoxide overproduction, and high blood pressure

Aithal G

R., Klaunig, J

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Additionally, mechanical injuries, such as joint wear, trigger inflammatory responses in cartilage and synovium, further upregulating the expression of matrix-degrading proteins, accelerating ECM degradation, and promoting OA progression (Maldonado and Nam, 2013)