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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

Acetyl-L-carnitine (ALCAR) : Able to cross the blood-brain barrier more efficiently and commonly used for cognitive support

Research published in Nutrients in 2024 examined L-carnitine's effects on body composition during caloric restriction, finding that supplementation helped preserve lean muscle mass while enhancing fat lossa critical consideration when prescribing weight loss medications (Fielding et al., 2024)

Co-authored by Erica Coates and Hannah Madden This article was co-authored by Erica Coates and by wikiHow staff writer, Hannah Madden

However, the reduction of the mentioned parameters was significantly prevented in the group receiving LC 200 mg/kg

Free Radic Biol Med 33(9):12901300 Go YM, Jones DP (2008) Redox compartmentalization in eukaryotic cells