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DarleyUsmar and coworkers have shown that HNE directly modifies Keap1, which allows Nrf2 to avoid degradation and migrate to the nucleus where it can bind to EpRE elements in the promoters of the human GCLC and GCLM genes (Levonen et al., 2004)

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Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence

Al ser un componente natural de la piel, es bien tolerado por todo tipo de piel, incluidas las sensibles o las que tiene tendencia acneica

C., Liu, Y., Dimitrijevic, N