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A therapeutically useful arginine depleting agent for cancer treatment should have low toxicity, non-immunogenic (to prevent antibody production and allergic reactions) and fast-acting (to delay emergence of drug resistance) with long circulation half-life (to achieve sustained arginine depletion)

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Sterile saline (0.9% NaCl solution) is another common diluent but is not ideal for all peptide applications, as the salt content can affect peptide stability

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Some are made following rigid pharmaceutical guidelines, while others are made by compounding pharmacies or online sellers with minimal regulation