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Ferroptosis and necroptosis have been identified as potential drivers of nerve injury, ischemiareperfusion injury, and kidney degeneration, suggesting inhibitors of these processes have huge potential as novel drug candidates (Park et al

Animal studies further indicate parenchymal accumulation and microglial activation, where intracellular 50500 nm particles tend to correlate with cytotoxic effects ( 3.2 Oxidative stress and neuroinflammation Oxidative stress is a central mechanism in MPs-induced neurotoxicity

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Liu, M., Sharma, M., Lu, G