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The outcome of this competition depends from the Cu(II)-binding affinities and concentrations of HSA, CuHSA and His according to the following simplified reaction scheme: HSA and His are present in the blood serum at average 650 M and 75 M concentration respectively 22,42,43,44

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However, whether excess hemin exposure from the hemolysis in SCD will affect CBS expression and the generation of GSH in oxidative and ferroptosis stress response has not been investigated

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