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These structural ZF sites are coordinatively saturated, i.e., they lack a solvent-accessible or open coordination site and are thought to be kinetically and/or thermodynamically stable, exhibiting very slow off rates

doi: 10.2337/dc06-1216

Sezer, R

They look at the patients needs and health

doi: 10.1186/s12934-021-01520-7 377 von BernhardiR.CornejoF.ParadaG

Furthermore, a possible link might exist between MET dysregulation and immunotherapy, leading to a growing investigation into the rationale behind combining MET TKIs with ICIs