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Dosage Dosing is individualized to body weight, severity of deficiency, and clinical context

At the metabolic input level, the System Xc transporter, composed of solute carrier family 7 member 11 (SLC7A11) and solute carrier family 3 member 2, mediates cystine uptake, providing essential precursors for GSH synthesis (147,153155)

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For example, a dysbiotic microbiota can promote ferroptosis by suppressing SLC7A11 expression, which limits cysteine uptake and GSH synthesis, while concurrently enhancing acyl-CoA synthetase long-chain family member 4 (ACSL4)-driven lipid peroxidation (41)

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