& Bouillaud, F
Efstratiadis A Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (IGF-1r)
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The main molecular mechanisms involved in the modulation of eryptosis studied to date, including intracellular calcium levels, ceramide, ROS, NO, changes in cellular energy metabolism, PS externalization, ion channel regulation, Fas-mediated signaling pathways, kinase-associated, and caspases activation, among others represent potential targets for inducing or inhibiting erythrocyte death
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Studies have found that the reduction of AMPK activity is an important pathological feature of NAFLD, and targeted activation of the AMPK signaling pathway can significantly improve liver lipid metabolism disorders and related pathological injuries (Figure 3)
