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Post-infusion CAR T cells in bone marrow (BM) of LTR have high immunometabolic plasticity and mTOR-pS6 expression supported by the BM microenvironment
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Cells were suspended in Seahorse XF RPMI medium (200 ul/well, Agilent, 103576-100) supplemented with 10 mM glucose, 2 mM glutamine, and 1 mM sodium pyruvate
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A key aspect of T-cell activation is the formation of the immunological synapse, a specialized interface that coordinates T cell receptor (TCR) signaling and adhesion
