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Additionally, cytosolic LPS is directly sensed by inflammatory caspases (e.g., Caspase-4), triggering non-canonical inflammasome responses and pyroptosis, which further amplifies systemic inflammation 144

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Indeed, in Hgf- or Met-null mice, the development of liver is severely impaired and the placental labyrinth is hypomorphic, leading to death in utero (Bladt et al., 1995

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