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7, July 2019, pp

For example, studies have shown that long-term ethanol exposure can downregulate the expression of serotonin receptors, particularly the 5-HT1A and 5-HT2A receptors (Dahchour and Ward 2024)

Example Gain-of-Function A number of endocrine diseases are caused by gain-of-function mutations of GPCRs

Stress, poor nutrition, sleep deprivation, chronic inflammation, and toxin exposure can all impair brain function

by Bianca Garilli, ND Non-alcoholic fatty liver disease (NAFLD), characterized by fat accumulation in the liver not caused by alcohol consumption, affects up to 25% of people in the US

Nature Communications (2025) 3