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The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade
If a patient takes more medication than is recommended, significant side effects such as renal failure or blood poisoning may appear
However, preclinical data on animals (gerbils) showed that both U-101033E and U-104067F can significantly attenuate the post-ischemic loss of dopaminergic nigrostriatal neurons (Miyaji et al., 2015
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Furthermore, surface charge of nanomaterials is essential in governing their cellular internalization, interaction with biomolecules or cellular organelles
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