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Emerging evidence indicates that features of aberrant trained immunity are present in patients with inflammatory disorders and chronic comorbidities, providing a theoretical framework for reinterpreting disease mechanisms from an innate immune memory perspective

1828, no

bradykinesia (slowness of movement, including difficulty planning, initiating and executing movement, as well as hindrance of the performance of sequential and simultaneous movement)

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These are legitimate scientific measurements, but they are surrogate readouts, not clinical outcomes that patients or clinicians experience