433 Overall, spermidine, with its natural origin, few side effects, and convenient access through diet or supplements, is poised to become a pivotal tool for future pro-longevity interventions
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Integration of network pharmacology and untargeted metabolomics reveals Changpu Sans antidepressant mechanisms via tryptophan metabolism
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To evaluate the therapeutic efficacy of LXR inverse agonists in vivo, we used three different dysmetabolic rodent models, including high-fat diet (HFD)-induced obese (DIO) mice, HFD-fed Zucker diabetic fatty (ZDF) rats and HFD-fed SpragueDawley (SD) rats (Extended Data Fig