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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells

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Elevated ROS formation in the vessel wall is a key feature of cardiovascular disease and contributes to endothelial dysfunction, vascular inflammation, and cardiovascular remodeling (6)

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