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Stimulation of the PI3K/Akt/mTOR protein synthesis pathway: Upon receptor activation, IGF-1 LR3 triggers intracellular cascades including PI3K and Akt phosphorylation

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Not unexpectedly, neurotrophic factors have been considered as treatment options for many neurodegenerative diseases, including Alzheimers disease (see reviews: Calissano et al., 2010

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Liochev SI, Fridovich I

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TB-500 TB-500 ( Ac-LKKTETQ ) is a synthetic heptapeptide that corresponds to the N-acetylated active fragment (amino acids 1723) [1] of the endogenous signalling factor thymosin beta-4

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