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Available from: National Institutes of Health, Office of Dietary Supplements

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The polysaccharides modulate NF-kappaB activity in keratinocytes, while betulinic acid suppresses inflammatory pathways in barrier-compromised skin

While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful