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Anti-inflammatory (preclinical): KPV has shown anti-inflammatory activity in cell and animal models [11]

Topical application in women with photodamaged skin showed a significant reduction in lines and wrinkles as well as improved skin thickness compared to the placebo and Vitamin K cream after 12 weeks of application

But if enzymatic function is impaired, nutrient cofactors are deficient, or toxins/ microbial byproducts inhibit pathways, these can become blocked, causing abnormal organic acid buildup in urine

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doi: 10.3389/fimmu.2021.616394

AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia