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Subsequently, a safety factor should be employed to derive the maximum recommended starting dose (MRSD) from the HED of the most relevant species

Alterations in cognitive function, often described as chemobrain, is a frequent consequence of chemotherapy, characterized by difficulties related to memory, attention, and reaction speed (Matsos et al., 2017)

It is vital to reestablish blood flow, but this act also contributes to neuronal injury by activating an immunological response and leading to endotoxicity, neuroinflammation, and oxidative and nitrosative stress, thereby worsening the outcome of ischemia (Chamorro et al., 2016

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FPN1 functions in concert with ferroxidases such as HEPH and CP, which oxidize Fe 2+ to Fe 3+ , enabling its safe release into the systemic circulation (Zhou and Tan, 2017)

901 The DNA sequence of NOX4 contains iron-responsive element-like (IRE-like) sequences that typically bind to iron-regulatory protein 1 (IRP1)