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Variation in the mid region was increased in the 50M48 hour treatment relative to the 10M72 hour treatment

Malik Clinical Therapeutics.2021

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When tested in vivo , chronic ALC treatment could revert depressive-like behavior caused by unpredictable chronic mild stress, a rodent model of depression with high face validity and predictivity, and its behavioral effect correlated with upregulated expression of mGlu2 receptor in hippocampi of stressed mice

Many clinical observations suggest use 2-3 times per week rather than daily, with cycling periods to help maintain response over time

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