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and smoking cessation has been demonstrated to improve insulin sensitivity (Facchini et al., Neurological Mechanisms Underlying Suppressed Appetite Classical feeding regulators The reduction in energy intake associated with smoking shows a relationship to the effects of several brain appetite regulators, and indeed, nicotinic receptors have been demonstrated in the appetite regulating area of the hypothalamus (Jo et al., In studies of a mouse model of cigarette smoke exposure, the hypothalamic NPY concentration was significantly suppressed by smoke exposure, compared with food restriction (pair-feeding
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