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Neither peptide is FDA-approved as a standalone therapeutic, and evidence specific to perimenopausal populations remains limited

In contrast, Ascenzi et al

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and (b) more efficient conversion of glutamine to GABA, the major inhibitory neurotransmitter

The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

A catalog of the mouse gut metagenome