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While transgenic lines such as Tg(mpx:GFP) have enabled dynamic, real-time visualization of neutrophil migration and infiltration during inflammatory responses (Renshaw et al., 2006
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But this study adds another layer, showing VK2 also protects the actual cells in cartilage (chondrocytes) by stopping ferroptosis, a type of iron-driven cell death
Recent studies have reported that silent information regulator 1 (SIRT1), a class III protein deacetylase, is crucial for the control of cellular survival 17
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