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Combined GSH and AA homeostasis impairment and hyperdopaminergic state in Trkb Penk -KO mice affects energy metabolism, impacting neuronal viability before the onset of motor symptoms

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Women diagnosed with antiphospholipid antibody syndrome, vein thrombosis, inflammation, or genetic diseases were excluded

NADPH, GSH and GR were mixed in assay buffer before Grx was added and a baseline was recorded for 30 s

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In these conditions, bowel thickening and inflammation leads to poor absorption of nutrients and weight loss