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Nature 575(7784):693698 Yang JS et al (2025) ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

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This was despite some concerns outlined in briefing documents regarding Lillys trial methodology, including its use of the integrated Alzheimers Disease Rating Scale (iADRS) as the primary endpoint, the use of tau protein levels to decide study inclusion and the cessation of donanemab treatment in patients whose brain amyloid levels dropped past a certain, pre-specified threshold