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Research has shown that in patients with chronic arthritis, functional connectivity of the insula is closely associated with subjective fatigue and pain scores, suggesting that the insula plays a central role in integrating peripheral pathological signals with subjective experience (182)

Merriam GR, Schwartz RS, Vitiello MV

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longa chloroform extracts Three grams of each freeze-dried powdered Curcuma sample was macerated with 30 mL chloroform for 2 h, then centrifuged and filtered